Interleukin-4 protects from chemotherapy-induced peripheral neuropathy in mice modal via the stimulation of IL-4/STAT6 signaling
نویسندگان
چکیده
منابع مشابه
Chemotherapy-induced peripheral neuropathy.
PURPOSE/OBJECTIVES To review the literature documenting the scope, treatment, and prevention of chemotherapy-induced neuropathy. DATA SOURCES Published abstracts, primary research literature, and textbook chapters. DATA SYNTHESIS Recent improvements in the management of other treatment-related toxicities have led to peripheral neuropathy becoming a dose-limiting toxicity of commonly used ch...
متن کاملChemotherapy-induced peripheral neuropathy
Neuropathy is associated with side effects of frontline chemotherapeutics, which is a prominent therapy utilized in prevalent cancers. Peripheral neuropathy negatively impacts quality of life in cancer patients and survivors. It also affects the dose plan of the treatment, thereby limiting the efficacy of the treatment. We searched the electronic database PubMed for pre-clinically and clinicall...
متن کاملFrequency of Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients in Sari Imam Khomeini Hospital
Background and purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating condition that may require reduction or discontinuation of chemotherapy. Identifying effective methods in treatment of established CIPN requires determining the frequency of CIPN. There is a lack of comprehensive studies on this issue, so, this study was conducted to investigate the frequency of periphe...
متن کاملGrading of chemotherapy-induced peripheral neuropathy.
Peripheral neuropathy can be defined as a derangement in structure and function of peripheral motor, sensory, and autonomic neurons [1], causing peripheral neuropathic symptoms and signs. In routine clinical practice settings, neuropathic symptoms are evaluated by a more or less standardized neurological history taking. Assessment of neuropathic signs is usually performed with bed-side clinical...
متن کاملRodent models of chemotherapy-induced peripheral neuropathy.
Peripheral neuropathy is a common and dose-limiting side effect of many chemotherapeutic drugs. These include platinum compounds, taxanes, vinca alkaloids, proteasome inhibitors, and others such as thalidomide and suramin. Although many rodent models have been developed using either mice or rats, there is limited consistency in the dose or mode of delivery of the drug; the sex, age, and genetic...
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ژورنال
عنوان ژورنال: Acta Cirurgica Brasileira
سال: 2018
ISSN: 1678-2674,0102-8650
DOI: 10.1590/s0102-865020180060000003